Dehydroepiandrosterone Sulfate (DHEA-S)What is DHEA-S?
Dehydroepiandrosterone sulfate (DHEA-S) is an important precursor hormone and is the highest circulating steroid present in the human body. DHEA-S is predominantly produced by the adrenal glands and is an excellent indicator of adrenal hormone production. Although DHEA-S itself only has weak hormonal activity, it can be metabolized into more active androgens (e.g. testosterone) and estrogens (e.g. estradiol). DHEA-S contributes to male traits and also has neurosteroid activity, meaning it can influence brain function.
Abnormal DHEA-S Levels
Excess DHEA-S can be a sign of adrenal tumours (malignant or benign), enlargement of an adrenal gland, congenital adrenal hyperplasia, or polycystic ovary syndrome (in females). Congenital adrenal hyperplasia is a series of inherited adrenal gland disorders that cause early puberty in males, and abnormal hair growth and irregular menstrual periods in females.
Low DHEA-S levels can be caused by type 2 diabetes, adrenal deficiency, kidney complications, and anorexia. The symptoms can include prolonged fatigue, difficulty concentrating, lower sex drive, increased risk of osteoporosis and dementia.
Early puberty in males 
Excess body & facial hair in females
Irregular menstruation in females
Fertility issues in females
Acne
Masculine body changes in females
Difficulty concentrating
Reduced sex drive
Fatigue
Increased risk of osteoporosis
Increased risk of dementia
