All men are at risk of prostate cancer. This simple PSA test can detect it early.
The prostate is the part of the male reproductive system that produces fluid that makes up a part of semen. Prostate cancer is the second most common cancer in American men, but often remains undetected until the late stages when it is more difficult to treat.
Prostate specific antigen (PSA) is a serine protease glycoprotein, which is predominantly produced in the prostate. Blood levels of PSA are a useful indicator of prostatic pathology, to evaluate men at risk of prostate cancer, and for assessment after treatment.
In normal healthy individuals, PSA is secreted into the seminal fluid in high concentrations to liquefy seminal gel and help increase sperm mobility. A small amount of PSA is also normally found in the blood as a result of leakage from the prostate gland.
Why consider this test?
- Prostate cancer is the second most common cancer in American men
- Prostate cancer is a frequent cause of cancer-associated death in men
- Early diagnosis of prostate cancer is important for the best chance of successful treatment
- A family history of prostate cancer may increase your risk
- African Americans have an increased risk of prostate cancer
- Men with possible symptoms of prostate cancer should consider this test for early diagnosis
- This test can also be used to monitor PSA levels in individuals who are receiving treatment for prostate cancer.
- The CDC currently recommends that men who are 55 to 69 years old should make individual decisions about being screened for prostate cancer with a prostate specific antigen (PSA) test.
Symptoms of prostate cancer
Pain in lower pelvic area, lower back, hips, or upper thighs
Frequent urination which can be painful
Blood in urine
Loss of appetite
Weight loss
Painful ejaculation
What’s included in the Prostate Screening (PSA) Test?

Total PSA
Total prostate specific antigen (total PSA) includes both free PSA and PSA complexed to alpha-1-antichymotrypsin. Healthy males should have total blood PSA levels less than 4 ng/mL. Higher levels occur in individuals with benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer (4 – 30 ng/mL), with very high levels (>30 ng/mL) occurring at higher frequencies in men with advanced stages of prostate cancer.

Free PSA
Most prostate specific antigen (PSA) detected in the blood is complexed to alpha-1-antichymotrypsin. However, a small proportion is in the free form, and is known as free PSA. The measurement of free PSA is useful in individuals with total PSA levels between 4 and 10 ng/mL, as it can help determine whether or not elevated PSA levels are due to prostate cancer.

Calculated PSA Ratio
The calculated PSA ratio is an important indicator of the risk of prostate cancer based on total PSA and free PSA levels. Men with an elevated total PSA level may not be at increased risk of prostate cancer if they have a high proportion of free PSA. The PSA ratio is a useful tool to help determine which men should undergo further testing (e.g. biopsy) to test for prostate cancer.
How It Works
Step 1. Order your test.
Choose the test that matches your need from our large array of tests. The kit will be delivered to your doorstep. There is no need to leave the comfort of your home.
Step 2. Collect your sample.
Collect your sample using the included instructions. Return your sample using the prepaid, pre-addressed packaging provided.
Step 3. Access your results online
Your sample will be tested as soon as it arrives at our lab. Access your results securely online using your via Therizon Connect.

Use TherizonConnect to view your Test Results Quickly and Easily
The results are only available through therizon, a free, secure patient portal that you can access on your smartphone, tablet, or desktop. You can also share your results with your doctor, family, or friends.
PSA FAQ
Here are the answers to the most frequently asked questions about this test. Please feel free to contact us if you have any other questions.
What is prostate cancer?
The prostate is a small walnut-shaped gland in the pelvis of men. Prostate cancer is the second most frequently diagnosed cancer (after skin cancer) in men in the United States. There are often no symptoms in the early stages of prostate cancer. When symptoms do appear, they can include pain the lower pelvic area, lower back, hips, or upper thighs, frequent urination, hematuria, loss of appetite and weight, and painful ejaculation.
When to take the test?
When detected early, prostate cancer can be effectively treated. Analyses of blood PSA levels are the most accurate way to detect prostate cancer, particularly in the early stages. These analyses are usually combined with, or followed up by, digital rectal examination.
Are there medical professionals involved in the process?
All of our tests are developed with advice and input from medical professionals.
Will I receive any guidance with my results?
All result reports will include brief and easy to understand interpretations of each of the biomarkers tested. Background information is also available, but we recommend that you share your test results with your healthcare provider to obtain the most benefit from your test results.
How does the Prostate Screening (PSA) Test work?
Self-collect your sample following the detailed instructions included in the kit. Place your sample in the specimen bag provided and mail it back to the lab using the prepaid envelope inside the kit.
Our lab uses verified and approved chemiluminescent microparticle immunoassays (CMIAs) to accurately measure your total PSA and free PSA levels, and calculate the PSA ratio. Your results are available through our online portal as soon as testing is complete.
What are healthy PSA levels?
Healthy males should have total blood PSA levels less than 4 ng/mL. Higher levels occur in individuals with BPH, prostatitis, and prostate cancer (4 – 30 ng/mL), with very high levels (>30 ng/mL) occurring at higher frequencies in men with advanced stages of prostate cancer.
What are the limitations of this test?
- Other conditions (e.g. benign prostatic hyperplasia (BPH) and prostatitis) can also increase PSA levels
- Specific medications (e.g. for treating BPH and urinary conditions) may lower PSA levels
- Some men with prostate cancer have normal PSA levels
- Overdiagnosis is possible. This is when tumours are detected that are unlikely to ever cause any problems, and hence do not require treatment.
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